|
KMID : 0892920160250060333
|
|
Experimental Neurobiology
2016 Volume.25 No. 6 p.333 ~ p.341
|
|
|
Prefrontal Cortical Thickness Deficit in Detoxified Alcohol-dependent Patients
|
|
Bae Su-Jin
Kang Il-Hyang
Lee Boung-Chul
Jeon Yu-Jin
Cho Han-Byul
Yoon Su-Jung
Lim Soo-Mee
Kim Jung-Yoon
Lyoo In-Kyoon
Kim Ji-Eun
Choi Ihn-Geun
|
|
|
Abstract
|
|
|
|
Alcohol dependence is a serious disorder that can be related with a number of potential health-related and social consequences. Cortical thickness measurements would provide important information on the cortical structural alterations in patients with alcohol dependence. Twenty-one patients with alcohol dependence and 22 healthy comparison subjects have been recruited and underwent high-resolution brain magnetic resonance (MR) imaging and clinical assessments. T1-weighted MR images were analyzed using the cortical thickness analysis program. Significantly thinner cortical thickness in patients with alcohol dependence than healthy comparison subjects was noted in the left superior frontal cortical region, correcting for multiple comparisons and adjusting with age and hemispheric average cortical thickness. There was a significant association between thickness in the cluster of the left superior frontal cortex and the duration of alcohol use. The prefrontal cortical region may particularly be vulnerable to chronic alcohol exposure. It is also possible that the pre-existing deficit in this region may have rendered individuals more susceptible to alcohol dependence.
|
|
|
KEYWORD
|
|
|
Alcoholism, Cerebral Cortex, Frontal Lobe, Magnetic Resonance Imaging
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|